Professor Graham Lord
Professor of Medicine
Professor of Medicine, King’s College London
Honorary Consultant in Nephrology and Transplantation, Guy’s and St. Thomas’ NHS Foundation Trust
Head of Department of Experimental Immunobiology, King’s College London
- Director of NIHR Biomedical Research Centre, Guy’s and St. Thomas’ Hospital and King’s College London
Graham M. Lord MA, MB BChir, FSB, FRCP, PhD, qualified in medicine from Cambridge University in 1991 and undertook a period of general clinical training as a junior doctor in Cambridge, Hammersmith, Oxford and the Brompton. Following specialisation in Nephrology, Transplantation and General Medicine at the Hammersmith, he undertook a period of research in Transplantation Immunology at Imperial College London that led to a PhD in 2000, funded by an MRC Clinical Training Fellowship. He was appointed as a Consultant in Nephrology and Transplantation at the Hammersmith in 2003. From 2003-2006, funded by an MRC Clinician Scientist award, he was a visiting scientist at Harvard University and came back to the UK to become the Chair of Medicine at King’s in 2006. Professor Lord has built up a research group at King’s College London investigating fundamental immune cell biology and the translation of this knowledge to the diagnosis and treatment of patients with organ transplant rejection and autoimmune diseases. As an NHS consultant, he practices clinical nephrology with a particular interest in renal and pancreatic transplantation.
Graham M. Lord MA, MB BChir, FSB, FRCP, PhD, qualified in medicine from Cambridge University in 1991 and undertook a period of general clinical training as a junior doctor in Cambridge, Hammersmith, Oxford and the Brompton. Following specialisation in Nephrology, Transplantation and General Medicine at the Hammersmith, he undertook a period of research in Transplantation Immunology at Imperial College London that led to a PhD in 2000, funded by an MRC Clinical Training Fellowship.
He was appointed as a Consultant in Nephrology and Transplantation at the Hammersmith in 2003. From 2003-2006, funded by an MRC Clinician Scientist award, he was a visiting scientist at Harvard University and came back to the UK to become the Chair of Medicine at King’s in 2006.
Professor Lord has built up a research group at King’s College London investigating fundamental immune cell biology and the translation of this knowledge to the diagnosis and treatment of patients with organ transplant rejection and autoimmune diseases. As an NHS consultant, he practices clinical nephrology with a particular interest in renal and pancreatic transplantation.Last year, Professor Lord led the successful application for the NIHR Biomedical Research Centre at Guy's and St Thomas' and was appointed as Director of the Centre in 2012. In this role, he is responsible for the delivery of programmes of translational research with a significant part of the Centres' portfolio focussed on Regenerative Medicine and Cellular Therapy.
Dr. Maria Hernandez-Fuentes
Senior Fellow in Translational Research
Maria completed an MD in Universidad Complutense and her PhD in Immunology in Universidad de Alcalá, both in Madrid, Spain. In 1998 she came to the UK to do her first post-doc with Professor Robert Lechler, then at Imperial College, Hammersmith Hospital. In 2005 the research group moved to King's College London and from November 2006 she has been working with Professor Graham Lord. She has led the Clinical Research Team in the MRC centre for Transplantation since August 2009. The multidisciplinary Clinical Research Team is mainly focused on the development of biomarkers that could be predictive of kidney transplant outcome and could eventually enable biomarker-led individualisation of therapy. Genome wide association scans, measurement of gene expression and immunologic monitoring techniques are being used. Maria has a long standing interest in characterising and quantifying alloimmune responses in humans, and lately she has been working to investigate the role of B cells in transplantation tolerance. Maria is also a Fellow of the Higher Education Academy since 2007, and tutors, lectures and supervises students in immunology and Translational Medicine.
Dr. Ania Koziell
HEFC Senior Clinical Lecturer
Ian has worked for Graham Lord for a number of years at Imperial College and also in Boston before helping to set up the Lord lab at KCL in 2005. He currently acts as Lab Manger with responsibilty for ordering, invoicing, grant maintenance as well as having various safety and organisational duties. He also maintains an experimental role within the lab, working on a number of different research projects.
Executive Assistant to Professor Graham Lord
Dr. Arnulf Hertweck
Arnulf obtained his PhD in 2008 at Imperial College London working on the role of miRNAs in T cell development. His current project in the lab is focused on the transcriptional regulation of T cell lineage determination and plasticity.
Dr. Tom Lewis
Dr Thomas Lewis is a project administrator within the department. He read Chemistry with Mathematics at University College London graduating in 2002, and then completed a PhD in computational chemistry in 2005. After working within the pharmaceutical industry he pursued a change of career into clinical research. He recently worked as a Clinical Trial Administrator for a Clinical Research Organisation, gaining experience working for a variety of clients, both commercial and non-commerical. He joined the department in August 2009.
Dr. Refik Gökmen
Kidney Research UK Clinical Training Fellow
Refik is a Specialist Registrar in Nephrology on the North Thames rotation. He joined the lab in 2007 as a Kidney Research UK Clinical Training Fellow, and is working on a project aiming to define the transcriptional mechanisms of control of T cell regulatory and effector function in renal transplantation. http://www.kidneyresearchuk.org/content/view/92/150/
Dr. Nick Powell
Wellcome Trust Clinical Research Training Fellow (King's College London)
Honorary Clinical Lecturer (Bart's and the Royal London Hospital)
Specialist Registrar in Gastroenterology (Imperial College NHS Trust)
Nick is a Wellcome Trust clinical research training fellow. His main research interests concern gastrointestinal inflammation, particularly immune cell regulation at mucosal surfaces. His clinical training in gastroenterology and internal medicine has taken place in North West London and he still holds a clinical contract at Imperial College NHS Trust. He also holds an honorary clinical lecturer post at Bart's and the Royal London. Nick is an avid supporter of Aston Villa football club.
Dr. James Canavan
NIHR Clinical Training Fellow
James completed his clinical training in gastroenterology and internal medicine at Dublin, Kilkenny and Oxford, before moving to the LORD Lab as a clinical research fellow. His research interests include the role of regulatory T cells and dendritic cells in inflammatory bowel disease. He currently holds a NIHR Doctoral Research Fellowship.
BRC PhD Student
Katrina is a PhD student funded by the Biomedical Research Centre at Guyís and St Thomas'. She is working on the role of DNA variation, (Single Nucleotide Polymorphisms, SNPs and Copy Number Variations, CNVs), in altering the ability of transcription factors to bind to their target sites. Information about these SNPs and CNVs comes from large scale genome wide association studies (GWAS) which compare the DNA of healthy individuals to those with different diseases. There is evidence that, in some cases, individuals will have become more susceptible to a particular disease because of altered transcription factor binding and, therefore, altered transcription of key genes. We want to extend this research, making full use of the vast quantity of GWAS data now publically available.
Katrina is also involved with organising and promoting events on the Guy's campus to try and bring together PhD students from across KCL.
Estefania Nova Lamperti
Estefania studied Biochemistry at the Universidad de Concepcion in Chile for five years as her undergraduate, and later worked on an 18-month research project where she studied the role of mesenchymal stem cells in T cell subsets at the Universidad de Los Andes. She joined the department in October 2009 as a PhD student working on the Biomarkers of Tolerance project where she will be studying the B cell compartment in renal transplantation.
Dr. Ellen Marks
Ellen completed her PhD in 2009 at the universirty of Gothenburg, Sweden, where she investigated the role of costimulation in T cell mediated immunity to Chlamydia trachomatis. Ellens current project is focused on the role of microRNA's in T cell homeostasis.
Dr. Joana Willis
MRC Clinical Training Fellow
Jo is a Specialty Trainee in Nephrology on the South Thames rotation. She spent a few months in the lab as an NHR-funded Academic Clinical Fellow in 2010 and returned in October 2011 to take up a 3-year MRC Clinical Training Fellowship. She is investigating the role of microRNA142 in T regulatory cell development and function, and is also working on the development of novel biomarkers in transplantation.
Yogesh is working as a Biomedical Technician on a project studying Biomarkers of Tolerance in Renal Transplantation funded by GSTT. He obtained his first degree at University of Hertfordshire in Molecular Biology and Genetics in November 2010. He has worked as a Research assistant during his placement year from 2008-2009 looking at various signalling pathways involved in Stem Cells Differentiation into Cardiomyocytes. He joined the department in November 2010.
Jon has worked as a research assistant since January 2012. His BSc was in Human Sciences from King's College Hospital and went on to complete a Masters in Immunology at Imperial.